Anyway, it my original suggestion was based on the misconception that salvia itself contains cannabinoid agonists. But your comment on possible independent influences on calcium ion flux from rimonabant suggests that we wouldn't necessarily learn anything about the involvement of cannabinoid receptors in the overall salvia experience by trying salvia+rimonabant.
I think it's likely that salvinorin A has an effect on the endocannabinoid system (through some signal-transduction pathway initiated by it's action at the KOR). Rimonabant probably exerts its influence on the effects of salvinorin A because it blocks the effects that salvinorin exerts (indirectly) on the cannabinoid receptors. I was just pointing out that alternate mechanisms of rimonabant interacting with the KOR signal transduction pathway haven't been ruled out.
Alas, I don't have much background in neurochemistry, so all I really know is that the calcium ion flux affects synaptic transmission, and consequently affects behavior. I'll need to do more reading to go any deeper than that.
That's one of about four papers that have come out since I put together my rough notes on S. divinorum
. I'll have to track down a full copy of the paper to see what I can get out of it; I'm hesitant to comment based on the abstract alone.
But you have at least a first degree in biology/pharmacology right? Speaking from experience, as a hopefully not-too-stupid person, getting one's head even halfway around this kind of material is veeeery tricky. Even when one does, it's very difficult to do more than take papers individually at face value. You're making inferences from a whole body of knowledge. Whatever you're doing right now, as far as I can tell you're a scientist.
I appreciate that
. I think of myself as more of a well-informed amateur, but on the other hand my favorite author on psychoactive plants (Jonathan Ott) has only a bachelor's degree.
My bachelor's degree is in biochemistry. I think this sort of background is mostly helpful in terms of having confidence that one can
understand scientific literature, rather than actually providing much specific background on these topics. None of the courses dealt with the endocannabinoid or kappa-opioid systems in anything but the most cursory terms, but there were discussion groups where the focus was basically "read this paper and figure out the main points and implications that it presents." That's basically what I've done; taken notes on the key points of all the papers related to S. divinorum
that I can find, and now I'm working on organizing that information into a digestible structure.
I wonder whether your reading on salvia/norins could be form the basis for a review paper? (& whether getting one published might help you get where you want to go?)
I've been wondering the same thing myself. While there are a couple of decent reviews on the synthetic chemistry behind the development of salvinorin analogues, and of the structure-activity relationships seen in the analogues, there are no review papers (yet) on the pharmacology of salvinorin A. I have organized my notes on the pharmacology into an outline from which such a paper could be written, so perhaps it's worth submitting to some journals once I get a final draft finished. Most journals seem to only publish from authors affiliated with research institutions, but still, it's probably worth a try.
I also have written a review on what we know of the Nahua plant pipiltzintzintli
that I'm not sure what to do with. Whether it may be S. divinorum
has been the subject of a fair amount of debate (personally I think the evidence weighs heavily against this possibility). I'm not sure whether a periodical like the Journal of Psychoactive Drugs
might find it interesting enough to warrant publication. I'm hoping to put all this work into a short-but-dense (perhaps 180 page) reference book on S. divinorum
, its history, chemistry, and pharmacology sometime within the next year or so, but it might be better to try have some of the work published in scholarly journals as I write it. I'm new to the world of publishing (aside from one rather lengthy paper published in the Entheogen Review
) so I'm still trying to figure out protocol on things like that.