Search found 41 matches

by sage-borodin
Tue May 30, 2017 9:02 am
Forum: Science and Technology
Topic: This is LSD attached to a brain cell serotonin receptor
Replies: 0
Views: 1460

This is LSD attached to a brain cell serotonin receptor

A fascinating piece of research: A tiny tab of acid on the tongue. A daylong trip through hallucinations and assorted other psychedelic experiences For the first time, researchers at the UNC School of Medicine have discovered precisely what the drug lysergic acid diethylamide (LSD) looks like in its...
by sage-borodin
Tue May 30, 2017 8:52 am
Forum: Other Entheogens Discussion
Topic: N-3′-ethylaplysinopsin and related alkaloids
Replies: 3
Views: 2336

Re: N-3′-ethylaplysinopsin and related alkaloids

As I'm sure most of you are aware, the one pharmacological commonality shared by these psychedelic substances Is agonism at the 5HT2a/c receptor sites, and while these compounds may have action at other receptor sites, their primary activity seems to be heavily linked to these serotonin receptor sub...
by sage-borodin
Sat May 27, 2017 9:05 am
Forum: The Mush Room
Topic: Study confirms safety of psilocybin/psilocin
Replies: 3
Views: 2256

Study confirms safety of psilocybin/psilocin

To most of us this comes as no surprise. Pharmocologically the classic psychedelics are the safest psychoactive substances one can ingest. Though this study seemed to be a global survey of hospital visits and treatment relating to each substance, rather than each substances pharmacological profile. ...
by sage-borodin
Fri May 26, 2017 8:43 am
Forum: Philosophy and Spirituality
Topic: Hofmann interview excerpts
Replies: 0
Views: 1481

Hofmann interview excerpts

CG: What recommendations would you give to researchers now who want to work with these substances? AH: When LSD was distributed legally by Sandoz, there was a little brochure which was given together with the Delysid, which explained how LSD could be used. As an aid to psychoanalysis and psychother...
by sage-borodin
Thu May 25, 2017 8:47 am
Forum: Other Entheogens Discussion
Topic: N-3′-ethylaplysinopsin and related alkaloids
Replies: 3
Views: 2336

Re: N-3′-ethylaplysinopsin and related alkaloids

The affinity constants to serotonin receptor subtypes 5-HT2A and 5-HT2C are presented in Table 2. Compounds 4, 5 and 11 showed high affinity to the 5-HT2C receptor. In addition, aplysinopsins 5 and 11 showed also affinity to the 5-HT2A subtype. The highest affinity to 5-HT2C was established for 6-b...
by sage-borodin
Tue May 23, 2017 9:40 am
Forum: Philosophy and Spirituality
Topic: Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY
Replies: 2
Views: 1182

Re: Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY

In the Middle Ages, the church forbade dissection of human bodies, and medical students would visit battlefields and the gallows at night, and steal the bodies of victims of war and executed prisoners, in order to learn human physiology. Where that spirit of scientific courage has gone, I don't kno...
by sage-borodin
Tue May 23, 2017 9:37 am
Forum: Salvia Discussion
Topic: brain broke
Replies: 15
Views: 8725

Re: brain broke

I transcribed this excerpt from a terence McKenna lecture given in boulder, colorado titled "in search of the original tree of knowledge", the section in bold where terence is describing the experience which is about to occur as being like a "tidal wave" or "bomb blast" reminded me of the comment ma...
by sage-borodin
Tue May 23, 2017 9:12 am
Forum: Salvia Discussion
Topic: brain broke
Replies: 15
Views: 8725

Re: brain broke

2ofme, your last post reminded me of the hermetic position regarding human beings and their relation to God, below are some excerpts from a lecture given by terence McKenna on the topic of hermeticism and alchemy, here he elaborates on the concept that "man is the brother of God" I enjoy contemplati...
by sage-borodin
Mon May 22, 2017 8:25 am
Forum: Philosophy and Spirituality
Topic: Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY
Replies: 2
Views: 1182

Re: Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY

Casey hardison's last words for Nick: The undaunted spirit and psychedelic warrior of love and light, Nick Sand, the outlaw chemist, died in his sleep on Monday April 24th at the age of 75. Most famous for the Orange Sunshine brand of LSD distributed by the Brotherhood of Eternal Love, Nick Sand was...
by sage-borodin
Mon May 22, 2017 8:15 am
Forum: Philosophy and Spirituality
Topic: Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY
Replies: 2
Views: 1182

Nick Sand May 10, 1941 -- April 24, 2017 BY TIM SCULLY

Rest in peace Nick, your ideas, your courage, and you actions forever changed the world. In the Middle Ages, the church forbade dissection of human bodies, and medical students would visit battlefields and the gallows at night, and steal the bodies of victims of war and executed prisoners, in order ...